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You are here:Home » Antibodies » Abs to DNA Replication, Repair » Anti -Mre11A (DNA Replication, Repair and Recombination Factor)

Anti -Mre11A (DNA Replication, Repair and Recombination Factor)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E
The hMre11-hRad50-NBS1 protein plays a central role in the human cellular DNA Damage response, with recent studies indicating that these proteins help link DNA-damage detection to DNA-repair and cell cycle-checkpoint functions. This protein complex has been implicated in the activation of cell cycle-regulatory pathways, due to the fact that the NBS1 gene mutates in the chromosomal-instability syndrome, Nijmegen breakdown syndrome (NBS), which is characterized by increased cancer incidence, cell cycle checkpoint defects, and ionizing radiation sensitivity. HMre11-hRad50 foci form in response to DNA double-strand breaks and rely upon a DNA damage-induced signaling pathway. However, hMre11 migrates to sites of damage while hRad51 does not localize at these sites. These findings are consistent with the distinct role of these proteins in DNA repair.
Catalog #M4687-10
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA (Serum Titer): 1:250,000
Western Blot: Preliminary results: HeLa cell line: band at 70 and 75kD, OVCAR-3 cell line: band at 70 and 75kD.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.4mg/ml
FormSupplied as a liquid in PBS pH 7.2, sodium azide, before the addition of glycerol to 40%.
PurityPurified by affinity chromatography.
ImmunogenSynthetic peptide C-IDAFKSTRQQPSRNV, corresponding to human Mre11A (KLH). MW: 80.5kD.
SpecificityRecognizes human Mre11A. Species Crossreactivity: rodent.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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