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You are here:Home » Antibodies » Abs to Mucin » Anti -Mucin 5AC (MUC5AC, Apomucin, Gastric Mucin, Major Airway Glycoprotein, MUC5, Mucin 5 Subtype AC Tracheobronchial, Mucin 5 Subtypes A and C, Mucin 5 Subtypes A and C Tracheobronchial/gastric, Mucin 5AC Oligomeric Mucus/gel Forming, Tracheobronchial Mucin,

Anti -Mucin 5AC (MUC5AC, Apomucin, Gastric Mucin, Major Airway Glycoprotein, MUC5, Mucin 5
Subtype AC Tracheobronchial, Mucin 5 Subtypes A and C, Mucin 5 Subtypes A and C
Tracheobronchial/gastric, Mucin 5AC Oligomeric Mucus/gel Forming, Tracheobronchial Mucin,

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified E B IH
Mucins are heavily glycosylated glycoproteins, which constitute the major components of mucus which cover the surface of epithelial tissues. Nine distinct epithelial mucin genes (Muc-1, 2, 3, 4, 5AC, 5B, 6, 7 and 8) have been identified. Various immunohistochemical and in situ hybridization studies have shown that these mucins are differentially expressed in epithelia with cell-type specificity. Muc-5AC and Muc-6 glycoproteins are the first two mucins found in superficial epithelium and Muc-6 glycoprotein is found in the deep glands. The epitope is destroyed by beta-mercaptoethanol and proteases but not by periodate treatment. Antibody to gastric mucin M1 reacts with the gastric epithelium of normal human gastrointestinal tract as well as with the precancerous and cancerous colon, but not with normal adult colon. It also reacts with fetal colonic mucosa. Resurgence of gastric mucin reactivity during colonic carcinogenesis is due to re-expression of the peptide core of gastric (or fetal colonic) mucins.
Catalog #M4701-05H
ApplicationsSuitable for use in Immunohistochemistry, ELISA and Western Blot. Other applications not tested.
Recommended DilutionImmunohistochemistry (frozen): Ethanol fixed sections
Immunohistochemistry (paraffin): Protease pretreatment is recommended.
Western Blot: Strongly positive without mercaptoethanol pretreatment of mucin solution.
Optimal dilutions to be determined by the researcher.
Matched PairSuitable for use with M4701-05N in a sandwich ELISA.
HybridomaSP2/0 myeloma cells with spleen cells from BALB/c mice.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No1-13M1
HostMouse
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, 0.05% sodium azide.
PurityPurified
ImmunogenMucin isolated from an ovarian cyst fluid (pure endocervical type according to the Fenoglio's classification).
SpecificityRecognizes peptide core of gastric mucin (MUC5AC).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesMucin-5AC


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