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You are here:Home » Antibodies » Abs to Opioid Receptors, Agonists » Anti -Opioid Receptor, mu, CT, aa391-398 (MOR1)

Anti -Opioid Receptor, mu, CT, aa391-398 (MOR1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Highly Purified E B IC
Opioid receptors are G-protein coupled receptors. Most actions of exogenous opioids, such as morphine, are mediated through the mu-opioid receptor, including analgesia, tolerance and reward. In general, opioids modulate numerous central and peripheral processes including pain perception, neuroendocrine secretion and the immune response. The opioid signal is transduced from receptors through G proteins to various different effectors. Subsequent to G protein activation, several effectors are known to orchestrate the opioid signal. For example, activation of opioid receptors increases phosphatidyl-inositol turnover, activates K+ channels and reduces adenylyl cyclase and Ca++ channel activities.
Catalog #O7030-35
ApplicationsSuitable for use in ELISA, Western Blot, and Immunocytochemistry. Other applications have not been tested.
Recommended DilutionELISA: 20ug/ml
Western Blot: 50ug/ml. Please note that this antibody requires a low dilution for Western Blot.
Immunocytochemistry: 20ug/ml. This antibody has been found to stain specific cells in various regions of PLP fixed rat brain sections known to express the mu opioid receptor using ABC techniques.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~10mg/ml
FormSupplied as a liquid in PBS, 10mg/ml BSA, 40% glycerol.
PurityPurified by precipitation, dialysis and chromatography.
ImmunogenPeptide analogue of the carboxyl terminal of the mu opioid receptor covalently attached onto a carrier protein.
SpecificitySpecific for the COOH terminal of the mu opioid receptor.
CrossreactivityMu Opioid Receptor (391-398) 100%, Mu Opioid Receptor ~50%, Delta Opioid Receptor (360-371) 0%, Delta Opioid Receptor 0%, Kappa Opioid Receptor (346-380) 0%, Kappa Opioid Receptor 0%.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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