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Anti -Papilloma Virus, Human, Type 6, E7 Protein (hPV, HPV6 E7)
Anti -Papilloma Virus, Human, Type 6, E7 Protein (hPV, HPV6 E7)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
E B |
|
| The HPV genome is composed of six early (E1, E2, E3, E4, E6 and E7) and two late (L1 and L2) proteins. After the host cell is infected E1 and E2 are expressed first. High E2 levels repress expression of the E6 and E7 proteins. When the host and HPV genomes integrate, E2 function is disrupted, preventing repression of E6/E7. E6 and E7 are the HPV proteins associated with cancer as they inactivate two tumor suppressor proteins, p53 (inactivated by E6) and pRb (inactivated by E7). | | | Catalog # | P3105-37C | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilution | Optimal dilutions to be determined by the researcher. | | Hybridoma | Sp2/0 myeloma cells with spleen cells from Balb/c mice. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG3 | | Clone No | 11H13 | | Host | Mouse | | Concentration | As reported | | Form | Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | E7 protein from HPV type 6 coupled with APP | | Specificity | Recognizes HPV6 E7. Crossreacts with HPV types 11, 16 and 18. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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