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You are here:Home » Biochemicals » Biochem-Antibiotics » Penicillin G, Sodium Salt USP

Penicillin G, Sodium Salt USP


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Penicillin G is a broad based antibiotic used in mammalian cell culture. Penicillin G blocks the formation of bacterial cell walls, rendering bacteria unable to multiply and spread. The spectrum of activity of Penicillin G includes many aerobic and anaerobic gram-positive organisms. Aerobes susceptible to Penicillin G include most beta-hemolytic streptococci, beta-lactamase-negative staphylococci, Actinomyces species, some Bacillus anthracis, Corynebacterium species, and Erysipelothrix rhusiopathiae. Most species of anaerobes, including Clostridium species, but excluding beta-lactamase-producing Bacteroides species, are also susceptible to Penicillin G. Penicillin G is easily inactivated by beta-lactamases and has little efficacy against organisms that can produce these enzymes. In addition, Penicillin G is ineffective against those bacteria that are resistant by other mechanisms, such as having a relatively impermeable cell wall. Therefore, Penicillin G has little activity against many staphylococci and most gram-negative bacteria.
Catalog #P3200
AppearanceWhite to off white crystalline powder
IdentificationConforms to USP
Specific Rotation (C=0.7) +285 to +310°
pH 5.5-7.5
Loss on Drying 1.0%
Absorbance264nm: As reported
280nm: As reported
325nm: As reported
Related Substances 1.0%
2-Ethylhexanoic Acid 0.5%
CAS Number69-57-8
Molecular FormulaC16H17N2O4NaS
Molecular Weight356.37
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesBenzylpenicillin sodium; Sodium benzylpenicillinate

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