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P3272-04A Mouse Anti-Pepsinogen I

Specifications
References
Clone Type
Monoclonal
Host
Mouse
Source
Human
Isotype
IgG1
Clone Number
4C6.1
Grade
Ascites
Applications
E IHC WB
Crossreactivity
Hu
Gene ID
643834
Shipping Temp
Blue Ice
Storage Temp
-20°C

Pepsinogen I is a group of precursor molecules for pepsin. These proteins are solely synthetized and secreted into gastric lumen by chief (pepsin) cells and mucous neck cells in the gastric corpus (oxyntic mucosa). In atrophic corpus gastritis these cells disappear resulting in a decrease of the serum level of pepsinogen I and in a reduction of the number of pepsinogen I positive cells in gastric biopsies. The presence of positive immunostaining for pepsinogen I is a highly reliable sign for the acid-secreting oxyntic glands. In gastric heterotopia of the duodenal bulb, but not in gastric metaplasia, the oxyntic-type glands give a positive immunohistochemical reaction for pepsinogen I.

Applications
Suitable for use in Immunohistochemistry, Western Blot and ELISA. Other applications not tested.
Recommended Dilution
Immunohistochemistry: Paraffin Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after reciept.. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Pepsinogen I purified from human tissue
Form
Supplied as a liquid in PBS, 1% BSA, 0.09% sodium azide.
Purity
Ascites
Specificity
Recognizes human Pepsinogen I. Does not crossreact with human Pepsinogen II.
References
1. Varis K. Surveillance of pernicious anemia. In Precancerous Lesions of the Gastrointestinal Tract. Scherlock P, Morson PC, Barbara L, Veronesi U (eds), Raven Press, New York, 189-194, 1983. 2. Sipponen P, Kekki M, Haapakoski J, Ihamäki T, Siurala M. Gastric cancer risk in chronic atrophic gastritis: statistical calculations of cross sectional data. Int. J. Cancer, 35: 173-177, 1985. 3. Borch K, Axelsson CK, Halgreen H, Damkjaer Nielsen MD, Ledin T, Szesci PB. The ratio of pepsinogen A to pepsinogen C: a sensitive test for atrophic gastritis. Scand. J. Gastroenterol., 24: 870-876, 1989. 4. Varis K, Sipponen P, Laxén F, Samloff MI, Huttunen J, Taylor PR, Heinonen OP, Albanes D, Sande N, Virtamo V, Härkönen M, Helsinki Gastritis Study Group. Serum pepsinogen I in screening of atrophic corpus gastritis. Implications in early endoscopic diagnosis of gastric cancer and dysplasia. Scand. J. Gastroenterol., 2000. 5. Miki K, Ichinose M, Ishikawa KB, Yahagi N, Matsushima M, Kakei N, Tsukada S, Kido M, Ishihama S, Shimizu Y, Suzuki T, Kurokawa K. Clinical application of serum pepsinogen I and II levels for mass screening to detect gastric cancer. Jpn. J. Cancer Res., 84: 1086-1090, 1993.
USBio References
No references available
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