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You are here:Home » Antibodies » Antibodies-Plastin » Anti -Plastin L (PLSL, L Plastin, L-Plastin, LC64P, Lymphocyte Cytosolic Protein 1, LCP1, LCP-1, Plastin 2, Plastin-2)

Anti -Plastin L (PLSL, L Plastin, L-Plastin, LC64P, Lymphocyte Cytosolic Protein 1, LCP1,
LCP-1, Plastin 2, Plastin-2)


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Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IP IF
L-plastin is a leukocyte specific actin bundling protein from fimbrin family of proteins. It has two actin-binding domains and two EF hand type calcium-binding domains. It gets phosphorylated on the serine residue in its headpiece region in response to a variety of inflammatory stimuli. It is hypothesized that L-plastin may play a role in regulating integrin mediated adhesion in leukocytes. L-plastin is expressed in majority of human cancer cell lines derived from solid tumors. Its expression is positively upregulated by testosteronse in andrgen receptor positive prostrate and breast cancer cells through three androgen receptor binding elements located in the upstream region of the gene.
Catalog #P4268
ApplicationsSuitable for use in Western Blot, Immunofluorescence and Immunoprecipitation. Other applications not tested.
Recommended DilutionsWestern Blot: 1-2ug/ml for 2 hours at RT.
Immunofluorescence: Fixed in methanol or 3% paraformaldehyde.
Immunoprecipitation (Native): 2ug/mg protein lysate using Protein G.
Optimal dilution to be determined by researcher.
Positive ControlHuman polymorphonuclear neutrophils and monocytes, MCF-7, Jurkat cells.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
Clone No3F316
FormSupplied as a liquid in PBS, pH 7.4, 0.2% BSA, 0.09% sodium azide. Also available without BSA and azide. See P4268X.
PurityPurified by Protein G affinity chromatography.
ImmunogenHuman recombinant L-plastin protein. Cellular Localization
SpecificityRecognizes human LPL in Ca2+ independent fashion. Does not crossreact with T-or I-plastin. Does not cross react with mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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