Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a 57.6kD transcription factor belonging to the nuclear hormone receptor (NR1) family. PPARG is vital in the regulation of cellular differentiation, development and metabolism. PPARG is a key regulator of adipocyte differentiation and glucose homeostasis. In addition, PPARG is the main target of thiazolidinediones (TZDs), a class of drug used in diabetes mellitus and other diseases that feature insulin resistance. PPARG is widely expressed with high concentrations being found in adipose tissue.
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