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You are here:Home » Antibodies » Abs to Obesity Proteins » Anti -PPARg (Peroxisome Proliferator Activated Receptor gamma, PPAR-gamma, Nuclear Receptor Subfamily 1 Group C Member 3, NR1C3, PPARG)

Anti -PPARg (Peroxisome Proliferator Activated Receptor gamma, PPAR-gamma, Nuclear
Receptor Subfamily 1 Group C Member 3, NR1C3, PPARG)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E
PPARG is a 505aa nuclear protein belonging to the nuclear hormone receptor family and NR1 subfamily, and contains a nuclear receptor DNA-binding domain. It is a receptor that binds to peroxisome proliferators such as hypolipidemic drugs and fatty acids and controls the peroxisomal beta-oxidation pathway of fatty acids. It is thus a key regulator of adipocyte differentiation and glucose homeostasis. It negatively regulates macrophage activation, inhibiting production of monocyte inflammatory cytokines and regulating both native and acquired immune responses. It forms a heterodimer with the retinoic acid receptor RXRA called adipocyte-specific transcription factor (ARF6) and regulates transcription of various genes. Genetic variation in PPARG may influence body mass index (BMI) and abdominal body fat distribution. Defects in PPARG can lead to numerous diseases including type 2 insulin-resistant diabetes, hypertension, colon cancer, familial partial lipodystrophy type 3 (FPLD3), carotid intimal medial thickness 1 (CIMT1) and obesity. It is mostly expressed in adipose tissue while expression is lower in skeletal muscle, spleen, heart and liver.
Catalog #P5505-06G
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined.
FormSupplied as a liquid, 0.025% sodium azide, 50% glycerol.
PuritySerum
ImmunogenSynthetic peptide corresponding to aa284-298 (MMGEDKIKFKHITPL) of human PPARG.
SpecificityRecognizes human PPARg, isoform 2. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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