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You are here:Home » Antibodies » Abs to Enzymes, Methyltransferase » Anti -PRDM7 (Probable Histone-lysine N-methyltransferase PRDM7, PR Domain Zinc Finger Protein 7, PR Domain-containing Protein 7, PFM4)

Anti -PRDM7 (Probable Histone-lysine N-methyltransferase PRDM7, PR Domain Zinc Finger
Protein 7, PR Domain-containing Protein 7, PFM4)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E
It belongs to the family of PRDM protein family and contains a PR domain and 5 Kruppel Like-zinc finger motifs at the C-terminal region. It plays a pivotal role in inducing and regulating terminal differentiation of B-lymphocytes. It recruits HDAC and complex of Groucho/TLE family proteins to the DNA and actively represses vital genes required for B-cell proliferation including c-myc, CIITA promoter III, CD23b and PAX-5 promoter. PRDM1 silences IFNâ-gene expression by binding specifically to PRDI of the IFNâ gene promoter. It is continuously expressed in all Plasma cells, but is not detected in early bone marrow B-cells, memory B-cells in spleen and most germinal center B-cells. In myeloma cells, PRDI-BF1â, a truncated isoform of PRDM1 is expressed that has an impaired ability to repress transcription suggesting a clinical implication.
Catalog #P5750-45B
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined.
FormSupplied as a liquid, 0.025% sodium azide, 50% glycerol.
PuritySerum.
ImmunogenSynthetic peptide corresponding to aa66-81 (HFGPYEGRITEDEEAA) of human PRDM7.
SpecificityRecognizes human PRDM7 and PRDM9. Species sequence homology: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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