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Specifications

Clone Host Grade Applications Monoclonal Rat Supernatant IH

Collagen type I is present in soft connective tissue and bone where it represents approximately 90% of the organic matrix. Collagen type I is produced from procollagen when two teloterminal propeptides are digested from the procursor and released into the circulation. The propeptide levels can be measured in serum as indicators of collagen production. Elevated values of these propeptides in serum are found in patients with various bone metabolism defects. Procollagen type I C-terminal propeptide (PICP) has a molecular weight of approximately 100kD and the normal range in serum is 100-300ug/ml.
Catalog #	P9005-74A
Applications	Suitable for use in Immunohistochemistry. Not recommended for Western Blot. Other applications have not been tested.
Recommended Dilutions	Immunohistochemistry (Fresh frozen tissue sections): 1:10,000-1:50,000
	Immunohistochemistry (FFPE): 1:100-1:1000; Pretreatment with 1% trypsin, 20 minutes at RT.
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone Type	Monoclonal
Isotype	IgG1
Clone No	2Q576
Host	Rat
Source	Human
Concentration	Not Determined
Form	Supplied as a liquid.
Purity	Supernatant
Immunogen	Human Pro-collagen I
Specificity	Recognizes human Pro-collagen I. Labels the amino-terminal pro-peptide. Localized intracellularly in cells producing Pro-collagen I. Does not stain mature collagen fibers in tissue. Does not recognize mouse or rat samples.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.