protocadherin-S, protocadherin X, protocadherin 11X, PCDHX, PCDH11, PCDH-X, RP13-138P15.1, protocadherin Y, protocadherin 22, protocadherin 11 X-linked, OTTHUMP00000033077, PCDHY, PCDH22, PCDH11X, PCDH-PC, protocadherin 11 Y-linked, PCDH11Y

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 7 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene is located in a major X/Y block of homology and its most closely related cadherin superfamily member is located in this homologous region on the X chromosome. The protein is thought to play a fundamental role in cell-cell recognition essential for the segmental development and function of the central nervous system. Transcripts arising from alternative splicing encode isoforms with N- and C-terminal variation.