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You are here:Home » Antibodies » Antibodies-Cancer Markers » Anti -PRUNE (Prune homolog (Drosophila), DRES-17, HTCD37)

Anti -PRUNE (Prune homolog (Drosophila), DRES-17, HTCD37)


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Clone Host Grade Applications
Monoclonal Mouse Highly Purified B IH IC
PRUNE, the human homologue of the Drosophila gene, is located in 1q21.3, a region highly amplified in human sarcomas, malignant tumors of mesenchymal origin. Human prune (h-prune), a phosphoesterase DHH family appertaining protein, physically interacts with nm23-H1, a metastasis suppressor gene. h-prune is involved in cellular motility and metastasis formation. Metastatic breast cancers were found to overexpress h-prune; h-prune was also found to be highly expressed in colorectal and pancreatic cancers. Hence h-prune is considered useful as a marker for tumor aggressiveness.
Catalog #P9140
ApplicationsSuitable for use in Immunocytochemistry Immunohistochemistry and Western Blot. Not suitable for Immunoprecipitation. Other applications not tested.
Recommended DilutionsImmunocytochemistry: 1:100
Immunohistochemistry (Frozen): 1:100
Western Blot: 1:100-1:500
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
Clone No6D711
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by affinity chromatography. 80-90% (SDS-PAGE).
ImmunogenRecombinant human PRUNE.
SpecificityRecognizes human PRUNE. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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