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Anti -PRUNE (Prune homolog (Drosophila), DRES-17, HTCD37)
Anti -PRUNE (Prune homolog (Drosophila), DRES-17, HTCD37)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Highly Purified |
B IH IC |
|
| PRUNE, the human homologue of the Drosophila gene, is located in 1q21.3, a region highly amplified in human sarcomas, malignant tumors of mesenchymal origin. Human prune (h-prune), a phosphoesterase DHH family appertaining protein, physically interacts with nm23-H1, a metastasis suppressor gene. h-prune is involved in cellular motility and metastasis formation. Metastatic breast cancers were found to overexpress h-prune; h-prune was also found to be highly expressed in colorectal and pancreatic cancers. Hence h-prune is considered useful as a marker for tumor aggressiveness. | | | Catalog # | P9140 | | Applications | Suitable for use in Immunocytochemistry Immunohistochemistry and Western Blot. Not suitable for Immunoprecipitation. Other applications not tested. | | Recommended Dilutions | Immunocytochemistry: 1:100 | | Immunohistochemistry (Frozen): 1:100 | | Western Blot: 1:100-1:500 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgM | | Clone No | 6D711 | | Host | Mouse | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, 0.02% sodium azide. | | Purity | Purified by affinity chromatography. 80-90% (SDS-PAGE). | | Immunogen | Recombinant human PRUNE. | | Specificity | Recognizes human PRUNE. Species Crossreactivity: mouse. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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