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You are here:Home » Antibodies » Abs to Cancer Markers » Anti -PRUNE (Prune homolog (Drosophila), DRES-17, HTCD37)

Anti -PRUNE (Prune homolog (Drosophila), DRES-17, HTCD37)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Highly Purified B IH IC
PRUNE, the human homologue of the Drosophila gene, is located in 1q21.3, a region highly amplified in human sarcomas, malignant tumors of mesenchymal origin. Human prune (h-prune), a phosphoesterase DHH family appertaining protein, physically interacts with nm23-H1, a metastasis suppressor gene. h-prune is involved in cellular motility and metastasis formation. Metastatic breast cancers were found to overexpress h-prune; h-prune was also found to be highly expressed in colorectal and pancreatic cancers. Hence h-prune is considered useful as a marker for tumor aggressiveness.
Catalog #P9140
ApplicationsSuitable for use in Immunocytochemistry Immunohistochemistry and Western Blot. Not suitable for Immunoprecipitation. Other applications not tested.
Recommended DilutionsImmunocytochemistry: 1:100
Immunohistochemistry (Frozen): 1:100
Western Blot: 1:100-1:500
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgM
Clone No6D711
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by affinity chromatography. 80-90% (SDS-PAGE).
ImmunogenRecombinant human PRUNE.
SpecificityRecognizes human PRUNE. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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