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You are here:Home » Antibodies » Abs to Tumor Suppressors » Anti -PTEN Tumor Suppressor Protein (MMAC1, Phosphatase and Tensin, TEP1)

Anti -PTEN Tumor Suppressor Protein (MMAC1, Phosphatase and Tensin, TEP1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
PTEN (phosphatase and tensin homology on chromosome 10) dephosphorylates proteins and lipids such as AKT and phosphatidylinositol 3,4,5-triphosphate (PIP3) and therefore functions as a key regulatory enzyme in a central signal transduction pathway. It also interacts with proteins Shc and FAK to promote apoptosis when necessary and to regulate cell division and migration.1 PTEN is considered a tumor suppressor as loss-of-function mutations in PTEN often result in human cancers including melanoma and prostate carcinoma.2,3 PTEN is expressed in almost all tissues of the body as a 403 amino acid protein with an estimated molecular weight of 47kD.
Catalog #P9182-05H
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 2ug/ml
Immunohistochemistry (Formalin-fixed paraffin-embedded sections): 2ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlsA431 and HEK293
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~0.4mg/ml
FormSupplied as a liquid in TBS, pH 7.4, 0.1% BSA, 0.02% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to aa 254-270 (KVEFFHKQNKMLKKDKM) of human PTEN.
SpecificityRecognizes human PTEN. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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