The Ras/Raf/MEK/ERK signaling pathway conveys mitogenic and differentiation signals from the cell membrane to the nucleus, and controls the proliferation and differentiation of different cell types.1–3 The Raf kinase inhibitor protein (RKIP) interacts with Raf1, MEK, and ERK both in vitro and in vivo,4 interfering with this signaling cascade. RKIP’s mechanism of action has been identified; it inhibits the Raf/MEK/ERK pathway at the Raf-1/MEK interface, where it dissociates the Raf-1/MEK complex and acts as a competitive inhibitor of MEK phosphorylation by Raf.5
Product | Size | List | Your Price | Qty | Ext Price | ||||
---|---|---|---|---|---|---|---|---|---|
Subtotal: | Subtotal: | ||||||||
Subtotal: | Subtotal: | ||||||||
Total Coupon Savings: | Total Coupon Savings: | () | |||||||
Your cart is currently empty. | |||||||||
- Coupon Code |