RAMP2 is a 20kD member of the RAMP family of proteins. It is expressed on cardiomyocytes, vascular smooth muscle cells and endothelium, and interacts with CRLR to form a receptor complex for adrenomedullin (AM). AM induces vasodilation on AM1 receptor expressing cells. Mature mouse RAMP2 is a 145aa type I transmembrane glycoprotein that contains a 115aa extracellular domain (ECD) aa45-159 and a nine aa cytoplasmic region. Although the ECD contains no typical structural motifs, based on human, aa100-106 are critical for AM binding. Over aa45-159, mouse RAMP2 shares 57-83aa identity with human and rat RAMP2, respectively.