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You are here:Home » Biochemicals » Biochem-Retinoids » all-trans Retinoic Acid (Vitamin A Acid, ATRA, Tretinoin)

all-trans Retinoic Acid (Vitamin A Acid, ATRA, Tretinoin)

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Specifications

Retinoic acid (ATRA) is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). The bound RAR and RXR act as transcription factors that regulate the growth and differentiation of both normal and malignant cells. Cytochromes P450 (CYPs) catalyze the 4-hydroxylation of ATRA. Retinoic acid primes embryonic stem cells to become neurons.
Catalog #R1690-02
SourceSynthetic
AtmosphereInert gas
Purity 98%
FormYellow Solid
Melting Point173-175°C
SolubilityChloroform
StabilityLight and temperature sensitive.
Method for Determining IdentityProton NMR Spectroscopic Analysis.
TLC ConditionsSiO2: Hexane: Ethyl acetate:1:1; Visualized with UV and AMCS; Single spot; Rf=0.6.
Storage and StabilityMay be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular FormulaC20H28O2
Molecular Weight300.44
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.
Alternate namesVitamin A Acid, ATRA, Tretinoin


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