USBio Logo

S0055-11 Saccharocarcin B CAS: 158475-33-3

Specifications
References
CAS Number
158475-33-3
Grade
Highly Purified
Molecular Formula
C68H103NO20
Molecular Weight
1254.55600000000004
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
4°C/-20°C

Saccharocarcin B is an unusual tetronic acid structurally related to kijanimicin, chlorothricin, tetrocarcins and versipelostatin which has pronounced activity against Gram positive bacteria and Chlamydia trachomatis. Limited availability has restricted further investigation of this metabolite in the literature. However, several members of this class have received considerable literature focus. Versipelostatin was shown to inhibit transcription from the promoter of GRP78, a gene that is activated as part of a stress signaling pathway under glucose deprivation resulting in unfolded protein response (UPR). The UPR-inhibitory action was seen only in conditions of glucose deprivation and caused selective and massive killing of the glucose-deprived cells. Tetrocarcin A appears to target the phosphatidylinositide-3'-kinase/Akt signaling pathway.

Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility
Source
Amycolatopsis sp.
Purity
>99%
Form
White solid
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. A family of novel macrocyclic lactones, the saccharocarcins produced by Saccharothrix aerocolonigenes subsp. antibiotica. I. Taxonomy, Fermentation, Isolation, and Biological Properties. Horan A.C. et al. J. Antibiot., 1997, 50, 119. 2. A family of novel macrocyclic lactones, the saccharocarcins produced by Saccharothrix aerocolonigenes subsp. antibiotica. II. Physico-chemical Properties and Structure Determination. Hegde V.R. et al., J. Antibiot. 1997, 50, 126. 3. Effect on tumor cells of blocking survival response to glucose deprivation. Park H.R. J. Natl. Cancer. Inst. 2004, 96, 1300. 4. Apoptosis and inactivation of the PI3-kinase pathway by tetrocarcin A in breast cancers. Nakajima H. Biochem Biophys Res Commun. 2007, 356, 260.|
USBio References
No references available
Pricing
Order
Proceed to Checkout
Cart Summary
ProductSizeListYour PriceQtyExt Price
Subtotal:Subtotal:
Subtotal:Subtotal:
Total Coupon Savings:Total Coupon Savings:()
Your cart is currently empty.
- Coupon Code
Recently Viewed
  • Contact Us

    Visit our technical library or contact our support staff to answer your questions.

    Telephone:
    1-800-520-3011

    Library | Contact

    Distributors

    For customers outside of the United States, please use one of our many distributors.

    View Distributors

    Payment Methods

    We accept the following payment methods as well as pay-by-invoice.

    MasterCard Visa PayPal
    © 2023-2024 United States Biological - All Rights Reserved