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You are here:Home » Biochemicals » Biochem-Antibiotics » Saccharocarcin B

Saccharocarcin B

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Specifications

Saccharocarcin B is an unusual tetronic acid structurally related to kijanimicin, chlorothricin, tetrocarcins and versipelostatin which has pronounced activity against Gram positive bacteria and Chlamydia trachomatis. Limited availability has restricted further investigation of this metabolite in the literature. However, several members of this class have received considerable literature focus. Versipelostatin was shown to inhibit transcription from the promoter of GRP78, a gene that is activated as part of a stress signaling pathway under glucose deprivation resulting in unfolded protein response (UPR). The UPR-inhibitory action was seen only in conditions of glucose deprivation and caused selective and massive killing of the glucose-deprived cells. Tetrocarcin A appears to target the phosphatidylinositide-3'-kinase/Akt signaling pathway.
Catalog #S0055-11
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility
CAS Number158475-33-3
Molecular FormulaC68H103NO20
Molecular Weight1254.55600000000004
SourceAmycolatopsis sp.
Purity>99%
FormWhite solid
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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