SRCRB4D (Scavenger receptor cysteine-rich domain group B four B-type domain containing) is a 56kD (predicted), secreted member of the SRCR superfamily. It is widely expressed and likely plays some role in innate immunity. Mature human SRCRB4D is 528aa in length. It contains four SRCR domains (aa58-573), each of which possesses three intradomain disulfide bonds. Although it contains no potential N-linked glycosylation sites, other types of posttranslational modification cannot be ruled out. There are three potential isoform variants. One shows a three aa substitution for aa 271-575, a second shows an 11aa substitution for aa 1-24, and a third shows a 25aa substitution for aa1-416, accompanied by a six aa insertion after Gly445. Over aa 45-575, human and mouse SRCRB4D share 90% aa identity.
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