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Anti -SGLT-1 (Sodium Glucose Transporter 1)
Anti -SGLT-1 (Sodium Glucose Transporter 1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Serum |
E B |
|
| The kidneys play a major role in the regulation of glucose levels. Kidneys filter ~180g of glucose per day from the blood. Most of this glucose is reabsorbed back into the blood via the proximal tubules. Typically, glucose is first absorbed within epithelium by a specific transporter protein, sodium glucose co-transporters (SGLT), in the brush-border membrane. Then it is transported out of the cell across the basolateral membranes by a facilitated sugar transporter (GLUTs). At least 3 members of SGLTs (SGLT1-3) have been cloned and characterized from various species. Individual members of this family have identical predicted secondary structures with up to 14 transmembrane domains. SGLT1-3 genes code for protein of ~659-672 residues (75kD). Both N- and C-termini are predicted to be extracellular. There is ~60-70% homology between SGLT1-3. SGLTs transport a-methyl-D-glucoside (a-MDG) is a non metabolized model substrate, in Na-dependent manner. SGLT1 does not discriminate a-MDG, glucose, and galactose. SGLT2/3 do not transport D-galactose efficiently. | | | Catalog # | S1010-86A | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 1:1000-1:5000 . ~70-77kD. | | ELISA: 1:10,000-1:50,000. Coat ELISA plates with control peptide at 1ug/ml. | | Optimal dilutions to be determined by the researcher. | | Control Peptide | S1010-86F | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Clone Type | Polyclonal | | Host | Rabbit | | Source | Mouse | | Concentration | Not determined | | Form | Supplied as a liquid, 0.05% sodium azide, 40% glycerol. | | Purity | Serum | | Immunogen | Synthetic peptide 19 AA sequence of mouse/rabbit SGLT-1(aa402-420; extracellular domain #4) (KLH coupled). | | Specificity | Recognizs SGLT-1. This sequence may also be conserved in other transporters. It is not known if S1010-86A will also identify SGLT-1 like, SGLT-2 or SGLT-3 proteins. Species crossreactivity | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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