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You are here:Home » Antibodies » Abs to Glucose Transporters » Anti -SGLT-1 (Sodium Glucose Transporter 1)

Anti -SGLT-1 (Sodium Glucose Transporter 1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E B
The kidneys play a major role in the regulation of glucose levels. Kidneys filter ~180g of glucose per day from the blood. Most of this glucose is reabsorbed back into the blood via the proximal tubules. Typically, glucose is first absorbed within epithelium by a specific transporter protein, sodium glucose co-transporters (SGLT), in the brush-border membrane. Then it is transported out of the cell across the basolateral membranes by a facilitated sugar transporter (GLUTs). At least 3 members of SGLTs (SGLT1-3) have been cloned and characterized from various species. Individual members of this family have identical predicted secondary structures with up to 14 transmembrane domains. SGLT1-3 genes code for protein of ~659-672 residues (75kD). Both N- and C-termini are predicted to be extracellular. There is ~60-70% homology between SGLT1-3. SGLTs transport a-methyl-D-glucoside (a-MDG) is a non metabolized model substrate, in Na-dependent manner. SGLT1 does not discriminate a-MDG, glucose, and galactose. SGLT2/3 do not transport D-galactose efficiently.
Catalog #S1010-86A
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000-1:5000 . ~70-77kD.
ELISA: 1:10,000-1:50,000. Coat ELISA plates with control peptide at 1ug/ml.
Optimal dilutions to be determined by the researcher.
Control PeptideS1010-86F
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceMouse
ConcentrationNot determined
FormSupplied as a liquid, 0.05% sodium azide, 40% glycerol.
PuritySerum
ImmunogenSynthetic peptide 19 AA sequence of mouse/rabbit SGLT-1(aa402-420; extracellular domain #4) (KLH coupled).
SpecificityRecognizs SGLT-1. This sequence may also be conserved in other transporters. It is not known if S1010-86A will also identify SGLT-1 like, SGLT-2 or SGLT-3 proteins. Species crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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