SREBP-1 and-2 are transcription factors which participate in the control of cholesterol homeostasis. SREBP proteins are attached to the endoplasmic reticulum and nuclear envelope. They are proteolytically cleaved and activated in response to conditions of low cellular sterol. Upon activation of SREBP-1 or -2, an ~480-500aa (N-terminal cleavage fragment of these proteins) enters the nucleus, activating transcription of enzymes and other proteins required for cholesterol synthesis. SCA (SREBP-cleavage activity) and caspase-3 proteases cleave SREBPs. SREBP proteins containing point mutations at caspase-3 cleavage sites (Asp460 in SREBP-1 and Asp468 in SREBP-2) do not become cleaved following induction of apoptosis. This suggests that SREBPs may play some role in apoptotic processes.
Product | Size | List | Your Price | Qty | Ext Price | ||||
---|---|---|---|---|---|---|---|---|---|
Subtotal: | Subtotal: | ||||||||
Subtotal: | Subtotal: | ||||||||
Total Coupon Savings: | Total Coupon Savings: | () | |||||||
Your cart is currently empty. | |||||||||
- Coupon Code |