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S9111-04 Sheep Anti-Synaptic adhesion-like molecule 2 (SALM2, LRFN1, leucine rich repeat and fibronectin type III domain containing 1, KIAA1484, Leucine-rich repeat and fibronectin type III domain-containing protein 1)

Specifications
Clone Type
Polyclonal
Host
Sheep
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Shipping Temp
Blue Ice
Storage Temp
-20°C

Synaptic adhesion-like molecule 2 (SALM2; also leucine-rich repeat and fibronectin type-III domain-containing protein 1 (Lrfn1) is a 105kD member of the Lrfn family of type I transmembrane glycoproteins. Human SALM2 is synthesized as a 771aa precursor that contains a 31aa signal sequence, a 505aa extracellular domain, a 21aa transmembrane region, and a 214aa cytoplasmic region. The ECD consists of seven leucine-rich repeats, an IgC2-like domain, and a fibronectin type-III domain, tandemly aligned in that order. In addition, there are two potential sites for N-linked glycosylation. The C-terminal region contains an intracellular PDZ binding domain, which is conserved among SALMs 1-3, but is absent in SALMs 4 and 5. Mature human SALM2 shares 96% and 95% sequence identity with mature mouse and rat SALM2, respectively.

Applications
Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution
Western Blot: 1ug/ml Optimal dilutions to be determined by the researcher.
Storage and Stability
Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Immunogen
CHO cell-derived recombinant human SALM2.
Form
Supplied as a lyophilized powder in PBS, 5% trehalose. Reconstitute with 500ul sterile PBS.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes human SALM2. Cross-reactivity: SALM3 (<5%), SALM4 (<5%). Species sequence homology: mouse (96%), rat (95%).
Conjugates
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