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T1030-06U Rabbit Anti-Tau, phosphorylated (Ser416) (Tau Protein, Microtubule-associated Protein, MAP)

Specifications
Clone Type
Polyclonal
Host
Rabbit
Source
Rat
Swiss Prot
P19332, P10636
Isotype
IgG
Grade
Affinity Purified
Applications
IHC WB
Crossreactivity
Mo Rt
Shipping Temp
Blue Ice
Storage Temp
-20°C

Tau is a key microtubule-associated protein that plays an important role in the formation of microtubules in axons (Binder et al. 1985). Six tau isoforms have been identified as products of a single gene produced by alternative mRNA splicing (Goedert 1990). Tau mutations have been implicated in many neurodegenerative disorders such as Alzheimer’s disease (AD), Pick’s disease and progressive supranuclear palsy. It has been well documented that hyperphosphorylated tau is a major component of paired helical filaments in AD brain (Lee 1995). Ser-416 has been demonstrated to be a major phosphorylation site in vitro by CaM kinase II (Steiner at al. 1990).

Applications
Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended Dilution
Western Blot: 1:1000 Immunohistochemistry: 1:200 Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser416 of rat tau, conjugated to KLH. Species sequence homology: bovine, canine and non-human primate
Form
Supplied as a liquid in 10mM HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.
Purity
Purified by affinity chromatography.
Specificity
Recognizes the ~59, 65 and 68kD isoforms of rat Tau when phosphorylated at Ser416. Species Crossreactivity: mouse
Conjugates
Pricing
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