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You are here:Home » Antibodies » Abs to Transcription Factors » Anti -Activating enhancer-binding protein 2-beta (AP-2 beta, TFAP2B)

Anti -Activating enhancer-binding protein 2-beta (AP-2 beta, TFAP2B)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified B
AP-2 beta (Activating enhancer-binding protein 2-beta; also TFAP2B) is a 52kD member of the AP-2 family of transcription factors. It is primarily a fetal-expressed protein, being found in renal and skin epithelial cells, as well as neuroblasts plus cells of the facial mesenchyme. In adults, AP-2 beta is expressed in renal epithelium. Human AP-2 beta is 460aa in length. It contains a transactivation domain (aa41-131), a DNA-binding motif (aa132-298) and a C-terminal dimerization region (aa299-439). SUMOylation occurs on Lys21, adding 15kD of MW in SDS-PAGE. AP-2 beta both homodimerizes, and heterodimerizes with AP-2 alpha and -2 gamma. Dimers appear important for facial and limb development.
Applications:
Suitable for use in Western Blot. Other applications not tested.
Catalog #T8195-52E3
Recommended DilutionWestern Blot: 1.0ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile 40-50% glycerol, PBS.. Aliquot and store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
ConcentrationAs reported
FormSupplied as a lyophilized powder in 0.2um sterile-filtered solution, PBS, 5% trehalose. Reconstitute with 40-50% glycerol, PBS.
PurityPurified by immunoaffinity chromatography.
ImmunogenRecombinant human AP-2 beta, aa121-218; Q92481 (E. coli).
SpecificityRecognizes human AP-2 beta at ~60kD.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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