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Anti -Activating enhancer-binding protein 2-beta (AP-2 beta, TFAP2B)
Anti -Activating enhancer-binding protein 2-beta (AP-2 beta, TFAP2B)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Goat |
Affinity Purified |
B |
|
| AP-2 beta (Activating enhancer-binding protein 2-beta; also TFAP2B) is a 52kD member of the AP-2 family of transcription factors. It is primarily a fetal-expressed protein, being found in renal and skin epithelial cells, as well as neuroblasts plus cells of the facial mesenchyme. In adults, AP-2 beta is expressed in renal epithelium. Human AP-2 beta is 460aa in length. It contains a transactivation domain (aa41-131), a DNA-binding motif (aa132-298) and a C-terminal dimerization region (aa299-439). SUMOylation occurs on Lys21, adding 15kD of MW in SDS-PAGE. AP-2 beta both homodimerizes, and heterodimerizes with AP-2 alpha and -2 gamma. Dimers appear important for facial and limb development. | | | | | | Applications: | | | Suitable for use in Western Blot. Other applications not tested. | | | Catalog # | T8195-52E3 | | Recommended Dilution | Western Blot: 1.0ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile 40-50% glycerol, PBS.. Aliquot and store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Goat | | Source | Human | | Concentration | As reported | | Form | Supplied as a lyophilized powder in 0.2um sterile-filtered solution, PBS, 5% trehalose. Reconstitute with 40-50% glycerol, PBS. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Recombinant human AP-2 beta, aa121-218; Q92481 (E. coli). | | Specificity | Recognizes human AP-2 beta at ~60kD. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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