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You are here:Home » Antibodies » Antibodies-Tubulin » Anti -Tubulin, beta 3 (Tubulin beta III, Tubulin beta-3 Chain, TUBB 3, TUBB3, Neuron Specific beta III Tubulin, beta-4, CFEOM3A, MC1R, Tubulin beta 4, TUBB 4, TUBB4)

Anti -Tubulin, beta 3 (Tubulin beta III, Tubulin beta-3 Chain, TUBB 3, TUBB3, Neuron
Specific beta III Tubulin, beta-4, CFEOM3A, MC1R, Tubulin beta 4, TUBB 4, TUBB4)


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Clone Host Grade Applications
Monoclonal Rabbit Purified B IP IH
The cytoskeleton consists of three types of cytosolic fibers: microtubules, microfilaments (actin filaments), and intermediate filaments. Globular tubulin subunits comprise the microtubule building block, with a/b-tubulin heterodimers forming the tubulin subunit common to all eukaryotic cells. y-tubulin is necessary to nucleate polymerization of tubulin subunits to form microtubule polymers. Many cell movements are mediated by microtubule action, including the beating of cilia and flagella, cytoplasmic transport of membrane vesicles, chromosome alignment during meiosis/mitosis, and nerve-cell exon migration. These movements result from competitive microtubule polymerization and depolymerization or through the actions of microtubule motor proteins.
3-tubulin (TUBB3) is one of six -tubulin isoforms and is expressed highly during fetal and postnatal development (axon guidance and maturation). Its expression levels decrease in the adult central nervous system (CNS) but remain high in the peripheral nervous system (PNS). Microtubules enriched in 3-tubulin are more dynamic than those composed of other -tubulin isoforms. Research studies have shown that mutations in the 3-tubulin gene TUBB3 cause ocular motility defects and other nervous system disorders. Furthermore, 3-tubulin is present in neoplastic but not in normal differentiated glial cells. Thus, 3-tubulin is a great neuronal marker.
Catalog #T9155-03L
ApplicationsSuitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.
Recommended DilutionsWestern Blot: 1:1000
Immunohistochemistry (Paraffin): 1:50. Use citrate as unmasking buffer.
Immunoprecipitation: 1:50
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
Clone No11C1087
ConcentrationNot Determined
FormSupplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1Mg/ml BSA, <0.02% sodium azide, 50% glycerol
ImmunogenSynthetic peptide corresponding to the carboxy terminus of human B3-tubulin.
SpecificityRecognizes endogenous levels of total human B3-tubulin. Does not recognize tubulin isoforms expressed in non-neuronal cells. Species Crossreactivity: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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