Mouse VE-Statin (vascular endothelial cell statin; also EGFL7) is a 41kD, secreted glycoprotein that belongs to an expanding family of EGF-like domain-containing proteins. It is an early marker of embryonic endothelial cells, and occurs in adult endothelium. Its secretion blocks smooth muscle migration. The mature molecule is 254 amino acids (aa) in length, and contains one N-terminal EMI domain (aa28-105), two EGF-like domains (aa 106-178), and a coiled-coil region (aa196-220). There is at least one isoform that shows a 13 aa deletion between aa236-248. Mature mouse VE-statin is 76% and 80% identical to canine and human VE-statin, respectively.