Technical Data
029432
CADM1 (Cell Adhesion Molecule 1, Immunoglobulin Superfamily Member 4, Igsf4, Nectin-Like Protein 2, Necl-2, Spermatogenic Immunoglobulin Superfamily, Sgigsf, Synaptic Cell Adhesion Molecule, Syncam, Tumor Suppressor in Lung Cancer 1, Tslc-1, Igsf4, Igsf4A
Description:
CADM1 is a tumor suppressor part of the immunoglobulin superfamily and has been found to show reduced expression in many different solid tumors. CADM1 has also been found to play a role in the formation of epithelia-like cell structure. Recent research has also linked CADM1 to mediating emotional and social behaviors and motor skills. CADM1 may also be important in psychiatric and behavioral disorders such as autism.

Applications:
Suitable for use in Western Blot and Immunocytochemistry. Other applications not tested.

Recommended Dilution:
Western Blot: 2ug/ml
Immunocytochemistry: 1:500
Optimal dilutions to be determined by the researcher.

Positive Control:
PC3 cell lysate

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabAffinity Purified
SizeStorageShippingSourceHost
100ug-20CBlue IceHumanRabbit
Concentration:
~1mg/ml
Immunogen:
Synthetic linear peptide corresponding to human CADM1.
Purity:
Purified by immunoaffinity chromatography.
Form
Supplied as a liquid in 0.1M Tris-glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.
Specificity:
Recognizes humam CADM1. Species Crossreactivity: Mouse and rat.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Takayanagi, Y., et al. (2010). Biochem Biophys Res Commun. 396(3):703-708. 2. Sakurai-Yageta, M., et al. (2009). Biochem Biophys Res Commun. 390(3):977-982. 3. Zhiling, Y., et al. (2008). Biochem Biophys Res Commun. 377(3):926-929. 4. Nowacki, S., et al. (2008). Oncogene. 27(23): 3329-3338.