Technical Data
031463
AADAT, ID (AADAT, KAT2, Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial, 2-aminoadipate aminotransferase, 2-aminoadipate transaminase, Alpha-aminoadipate aminotransferase, Kynurenine aminotransferase II, Kynurenine-oxoglutarate aminotransfer
Description:
This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Two alternative transcripts encoding the same isoform have been identified, however, additional alternative transcripts and isoforms may exist.

Applications:
Suitable for use in Western Blot and ELISA. Other applications have not been tested.

Recommended Dilutions:
Western Blot: 1:1000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
200ul-20CBlue IceHumanRabbit
Concentration:
As Reported
Immunogen:
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 196-224 in the central region of human AADAT, UniProt Accession #Q8N5Z0; NP_872603.1; NP_057312.1.
Purity:
Purified by Protein A and peptide affinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity:
Recognizes human AADAT.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Han, Q., et al. Biosci. Rep. 28(4):205-215(2008). 2. Rossi, F., et al. J. Biol. Chem. 283(6):3559-3566(2008). 3. Han, Q., et al. J. Biol. Chem. 283(6):3567-3573(2008). 4. Lamesch, P., et al. Genomics 89(3):307-315(2007). 5. Goh, D.L., et al. Mol. Genet. Metab. 76(3):172-180(2002)