Technical Data
ABCB4, ID (ABCB4, MDR3, PGY3, Multidrug resistance protein 3, ATP-binding cassette sub-family B member 4, P-glycoprotein 3)
The membrane-associated protein encoded ABCB4 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function.

Suitable for use in Western Blot, Immunohistochemistry, ELISA

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:50-100

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
PabIgGAffinity Purified
200ul-20CBlue IceHumanRabbit
As reported
ABCB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 632~661 amino acids from the central region of human ABCB4.
Purified by Protein G affinity chromatography.
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Human, mouse
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
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Jacquemin, E., Semin. Liver Dis. 21(4):551-562 (2001).
Smit, J.J., et al., Biochim. Biophys. Acta 1261(1):44-56 (1995).
Ruetz, S., et al., Cell 77(7):1071-1081 (1994).