Technical Data
033746
CEACAM7, ID (CEACAM7, CGM2, Carcinoembryonic antigen-related cell adhesion molecule 7, Carcinoembryonic antigen CGM2)
Description:
CEA-related cell adhesion molecule 7 (CEACAM7,CGM2) belongs to the carcinoembryonic antigen (CEA) family. It encodes a glycosyl phosphatidyl inositol (GPI)-linked glycoprotein which is only found on the apical surface of highly differentiated epithelial cells adult colon and on a small epithelial cell population in pancreatic ducts. CEACAM7 expression is completely lost upon malignant transformation already in hyperplastic polyps and early adenomas as well as in adenocarcinomas of the colon. Like all members of the CEACAM family, it consists of a single N domain, with structural homology to the immunoglobulin variable domains, followed by one immunoglobulin constantlike A domain.

Applications:
Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications have not been tested.

Recommended Dilutions:
Western Blot: 1:1000
Immunohistochemistry (FFPE): 1:10-1:50
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
200ul-20CBlue IceHumanRabbit
Concentration:
As Reported
Immunogen:
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 112-140 in the central region of human CEACAM7, UniProt Accession #Q14002; NP_008821.1.
Purity:
Purified by Protein A and peptide affinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity:
Recognizes human CEACAM7.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Messick, C.A., et al. Surgery 147(5):713-719(2010). 2. Douard, R., et al. Surgery 139(4):556-562(2006). 3. Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004). 4. Grimwood, J., et al. Nature 428(6982):529-535(2004). 5. Scholzel, S., et al. Am. J. Pathol. 156(2):595-605(2000)