Technical Data
HBG1, ID (HBG1, Hemoglobin subunit gamma-1, Gamma-1-globin, Hb F Agamma, Hemoglobin gamma-1 chain, Hemoglobin gamma-A chain)
The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.

Suitable for use in Western Blot and ELISA. Other applications not tested.

Recommended Dilutions:
Western Blot: 1:1000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
PabIgGAffinity Purified
200ul-20CBlue IceHumanRabbit
As Reported
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 56-85 in the central region of human HBG1, UniProt Accession #NP_000550.2; P69891.
Purified by Protein A affinity chromatography
Supplied as a liquid in PBS, 0.09% sodium azide.
Recognizes human HBG1.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Zhou, D., et al. Nat. Genet. 42(9):742-744 (2010). 2. Miccio, A., et al. Mol. Cell. Biol. 30(14):3460-3470 (2010). 3. Nuinoon, M., et al. Hum. Genet. (2009). 4. da Cunha, A.F., et al. Hemoglobin 33(6):439-447 (2009). 5. Hamid, M., et al. Hemoglobin 33(6):428-438 (2009)