Technical Data
IL12RB2, CT (IL12RB2, Interleukin-12 receptor subunit beta-2)
The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense.

Suitable for use in Western Blot, Immunohistochemistry, Flow Cytometry and ELISA. Other applications not tested.

Recommended Dilution:
Western Blot: 1:1000
Immunohistochemistry (FFPE): 1:10-1:50
Flow Cytometry: 1:10-1:50
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
PabIgGAffinity Purified
200ul-20CBlue IceHumanRabbit
As reported
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 756-783 in the C-terminal region of human IL12RB2 (Q99665).
Purified by Protein A affinity chromatography.
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Recognizes human IL12RB2.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) 2. Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) 3. Liu, X., et al. Nat. Genet. 42(8):658-660(2010) 4. Mizuki, N., et al. Nat. Genet. 42(8):703-706(2010) 5. Remmers, E.F., et al. Nat. Genet. 42(8):698-702(2010)