Technical Data
040108
PKP2, CT (PKP2, Plakophilin-2)
Description:
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13.

Applications:
Suitable for use in Western Blot, Immunohistochemistry, ELISA

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
200ul-20CBlue IceHumanRabbit
Concentration:
As reported
Immunogen:
PKP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 837-866 amino acids from the C-terminal region of human PKP2.
Purity:
Purified by Protein A affinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity:
Human
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Fressart, V., et al. Europace 12(6):861-868(2010)
Cox, M.G., et al. Circ Arrhythm Electrophysiol 3(2):126-133(2010)
Christensen, A.H., et al. Cardiology 115(2):148-154(2010)
den Haan, A.D., et al. Circ Cardiovasc Genet 2(5):428-435(2009)
Bhuiyan, Z.A., et al. Circ Cardiovasc Genet 2(5):418-427(2009)