Technical Data
044493
AIM2 (Interferon-inducible Protein AIM2, Absent in Melanoma 2)
Description:
AIM2 is a strong candidate as a tumor suppressor as it is a member of the HIN-200 (hemopoietic interferon-inducible, nuclear proteins containing a 200 amino acid repeat) family of proteins that have been shown to regulate cell growth and survival. The HIN-200 family of proteins consists of four members in human, IFI 16, MNDA, AIM2 and IFIXl. Recently it has been reported that AIM2 is a receptor for cytosolic dsDNA, which forms a novel inflammasome complex with ASC to activate caspase-1-mediated processing of IL-1beta.

Applications:
Suitable for use in Immunocytochemistry, Western Blot

Recommended Dilution:
Optimal dilutions to be determined by researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
MabIgG13B10Highly Purified
SizeStorageShippingSourceHost
100ug4C/-20CBlue IceHumanMouse
Concentration:
1mg/ml
Immunogen:
Human AIM2 (aa 1-186).
Purity:
>95% (SDS-PAGE)
Form
Supplied as a liquid in PBS, 10% glycerol, 0.02% sodium azide.
Specificity:
Recognizes human AIM2.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Product Reference:
Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2: K.S. Cresswell, et al.; BBRC 326, 417 (2005)
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA: T. Fernandes-Alnemri, et al.; Nature 458, 509 (2009)
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC: V. Hornung, et al.; Nature 458, 514 (2009)