Technical Data
044499
AMI-1 (Arginine N-methyltransferase inhibitor-1)
5mg
Biochemicals Storage: 4C/-20CShipping: Blue Ice
Potent, cell permeable and specific protein arginine N-methyltransferase 1 (PRMT1) inhibitor (IC50 = 8.8 M).
Does not compete for the AdoMet (S-adenosyl-L-methionine; SAM) binding site.
Blocks peptide substrate binding.
HIV-1 RT polymerase inhibitor (IC50 = 5.0 M).


Storage and Stability:
Short-term Storage: +4C
Long-term Storage: -20C
Stable for at least 2 years after receipt when stored at -20C.

Molecular Formula:
C21H12N2O9S2Na4

Molecular Weight:
592.4
Purity: >99% (NMR)

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Product Reference:
Small molecule regulators of protein arginine methyltransferases: D. Cheng, et al.; J. Biol. Chem. 279, 23892 (2004)
A novel mechanism for inhibition of HIV-1 reverse transcriptase: A.G. Skillman, et al.; Bioorg. Chem. 30, 443 (2002)
Inhibitory study of protein arginine methyltransferase 1 using a fluorescent approach: Y. Feng, et al.; BBRC 379, 567 (2009)


Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.