Technical Data
044600
Bilobalide
10mg
Biochemicals Storage: 4°C/-20°CShipping: Blue Ice
Neuroprotective. Mitochondrial gene expression regulator. ROS scavenger. Competitive GABA(A) receptor antagonist. Apoptosis inhibitor. CREB phosphorylation enhancer. Stimulates neurogenesis and synaptogenesis. Hepatic cytochrome P450 inducer. Activates the phosphatidylinositol 3-kinase (PI3K) dependent pathway.

Storage and Stability:
Short-term Storage: +4°C
Long-term Storage: -20°C
Working aliquots are stable for up to 3 months when stored at -20°C. Stable for at least 2 years after receipt when stored at -20°C.

CAS Number:
33570-04-6

Molecular Formula:
C15H18O8

Molecular Weight:
326.3
Purity: >95% (1H-NMR)

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Product Reference:
Bilobalid A, ein neues Sesquiterpen mit tert.-Butyl-Gruppe aus den Blättern von Ginkgo biloba L.: K. Weinges & W. Bähr; Liebigs Ann. Chem. 724, 214 (1969)
Protection of hypoxia-induced ATP decrease in endothelial cells by ginkgo biloba extract and bilobalide: D. Janssens, et al.; Biochem. Pharmacol. 50, 991 (1995)
Protection of mitochondrial respiration activity by bilobalide: D. Janssens, et al.; Biochem. Pharmacol. 58, 109 (1999)
Reactive oxygen species-induced apoptosis in PC12 cells and protective effect of bilobalide: L.J. Zhou & X.Z. Zhu; J. Pharmacol. Exp. Ther. 293, 982 (2000)
Bilobalide and neuroprotection: F.V. Defeudis; Pharmacol. Res. 46, 565 (2002) (Review)
Bilobalide, a sesquiterpene trilactone from Ginkgo biloba, is an antagonist at recombinant alpha1beta2gamma2L GABA(A) receptors: S.H. Huang, et al.; Eur. J. Pharmacol. 464, 1 (2003)
Neuroprotective effects of bilobalide, a component of Ginkgo biloba extract (EGb 761) in global brain ischemia and in excitotoxicity-induced neuronal death: K. Chandrasekaran, et al.; Pharmacopsychiatry 36 Suppl 1, S89 (2003)
Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons: F. Tchantchou, et al.; J. Alzheimers Dis. 18, 787 (2009)
Time-dependent induction of hepatic cytochrome P450 enzyme activity and mRNA expression by bilobalide in rats: Y. Taki, et al.; J. Pharmacol. Sci. 109, 459 (2009)
Bilobalide prevents apoptosis through activation of the PI3K/Akt pathway in SH-SY5Y cells: C. Shi, et al.; Apoptosis 15, 715 (2010)
Bilobalide regulates soluble amyloid precursor protein release via phosphatidyl inositol 3 kinase-dependent pathway: C. Shi, et al.; Neurochem. Int. 59, 59 (2011)


Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.