Technical Data
044665
Ciglitazone (()-5-thiazolidine-2,4-dione, U-63287)
1mg
Biochemicals Storage: +4C/+4CShipping: Blue Ice
Selective PPARgamma agonist (EC50=3uM). Hypoglycemic agent. Angiogenesis inhibitor. Anti-inflammatory. Apoptosis inducer.

Storage and Stability:
Short-term Storage: +4C
Long-term Storage: +4C
Stable for at least 2 years after receipt when stored at +4C.

CAS Number:
74772-77-3

Molecular Formula:
C18H23NO3S

Molecular Weight:
333.5
Purity: >99% (NMR)

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Product Reference:
The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones: T.M. Willson, et al.; J. Med. Chem. 39, 665 (1996)
Reduction of insulin resistance in obese and/or diabetic animals by 5--thiazolidine-2,4-dione (ADD-3878, U-63,287, ciglitazone), a new antidiabetic agent: T. Fujita, et al.; Diabetes 32, 804 (1983)
benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents: B.C. Cantello, et al.; J. Med. Chem. 37, 3977 (1994)
Peroxisome proliferator-activated receptor gamma ligands are potent inhibitors of angiogenesis in vitro and in vivo: X. Xin, et al.; J. Biol. Chem. 274, 9116 (1999)
The thiazolidinedione ciglitazone reduces bacterial outgrowth and early inflammation during Streptococcus pneumoniae pneumonia in mice: M.E. Stegenga, et al.; Crit. Care Med. 37, 614 (2009)
Ciglitazone, a novel inhibitor of lung apoptosis following hemorrhagic shock: R.S. Chima, et al.; Int. J. Clin. Exp. Med. 3, 1 (2010)


Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.