Technical Data
044687
CTRP13, globular domain, Recombinant, Human (His) (C1qTNF-related Protein 13, C1QTNF13, C1QL3, C1ql, K100, Complement C1q Tumor Necrosis Factor-related Protein 13)
10ug
Molecular Biology Storage: 4C/-20CShipping: Blue Ice
CTRP13 (C1qTNF-related protein 13) belongs to a highly conserved family of adiponectin paralogs. CTRP13 is an adipokine that promotes glucose uptake in adipocytes, myotubes and hepatocytes via activation of the AMPK signaling pathway. CTRP13 ameliorates lipid-induced insulin resistance in hepatocytes through suppression of the SAPK/JNK stress signaling that impairs the insulin signaling pathway. CTRP13 reduces glucose output in hepatocytes by inhibiting the mRNA expression of gluconeogenic enzymes, glucose-6-phosphatase and the cytosolic form of phosphoenolpyruvate carboxykinase. CTRP13 has insulin-sensitizing activity and is important in glucose homeostasis. CTRP13 is preferentially expressed by adipose tissue and the brain in mice and predominantly by adipose tissue in humans.

Sequence:
The globular domain of human CTRP13 (aa 120-255) is fused at the C-terminus to a His-tag.

Storage and Stability:
Short-term Storage: +4C
Long-term Storage: -20C
Stable for at least 1 year after receipt when stored at -20C. Working aliquots are stable for up to 6 months when stored at -20C.

Molecular Weight:
~16kD (SDS-PAGE)
Source: Human, E. coli
Purity: >95% (SDS-PAGE)
Form: Supplied as a lyophilized powder from a 0.2um-filtered solution in 50mM TRIS-Cl, pH 8.2, 150mM NaCl.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.