Debromohymenialdisine (DBH, DBHA-SKF, SKF 108753)
|Biochemicals||Storage: 4°C/-20°CShipping: Blue Ice|
Protein kinase C (PKC) inhibitor. Inhibits the ATP binding site.
Cytotoxic and insecticidal.
G2 DNA damage checkpoint inhibitor. Check point kinases 1 (Chk1) and 2 (Chk2) inhibitor.
Does not inhibit ataxia-telangiectasia mutated (ATM) or ATM-Rad3-related proteins.
MAP kinase kinase 1 (MEK-1) inhibitor.
Interleukin-1 (IL-1) inhibitor. Anti-osteoarthritic.
Potential anti-Alzheimer agent.
Storage and Stability:
Short-term Storage: +4°C
Long-term Storage: -20°C
Stable for at least 2 years after receipt when stored at -20°C.
Purity: >95% (HPLC)
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Effects of a protein kinase C inhibitor (PKCI) on the development of adjuvant-induced arthritis (AA) in rats: M. DiMartino, et al.; Inflamm. Res. 44, S123 (1995)
Bioactive alkaloids from the tropical marine sponge Axinella carteri: A. Supriyono, et al.; Z. Naturforsch. C 50, 669 (1995)
Inhibition of the G2 DNA damage checkpoint and of protein kinases Chk1 and Chk2 by the marine sponge alkaloid debromohymenialdisine: D. Curman, et al.; J. Biol. Chem. 276, 17914 (2001)
G2 DNA damage checkpoint inhibition and antimitotic activity of 13-hydroxy-15-oxozoapatlin: N.T. Rundle, et al.; J. Biol. Chem. 276, 48231 (2001)
Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1): D. Tasdemir, et al.; J. Med. Chem. 45, 529 (2002)
G2 checkpoint abrogators as anticancer drugs: T. Kawabe; Mol. Cancer Ther. 3, 513 (2004)
Cellular localization of debromohymenialdisine and hymenialdisine in the marine sponge Axinella sp. using a newly developed cell purification protocol: Y.F. Song, et al.; Mar. Biotechnol. 13, 868 (2011)