Technical Data
044916
IL-23p40 (Interleukin-23 Subunit p40, IL-23 Subunit p40, Interleukin-12 Subunit beta, IL-12B, Cytotoxic Lymphocyte Maturation Factor 40kD Subunit, CLMF p40, IL-12 Subunit p40, NK Cell Stimulatory Factor Chain 2, NKSF2)
Description:
IL-23p40 associates with IL-23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 binds to an heterodimeric receptor complex composed of IL-12RB1 and IL-23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. Defects in IL-23p40 are a cause of mendelian susceptibility to mycobacterial disease (MSMD). Genetic variations in IL-23p40 are a cause of susceptibility to psoriasis type 11 (PSORS11).

Applications:
Suitable for use in ELISA, Western Blot

Recommended Dilution:
Optimal dilutions to be determined by researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
MabIgG1,kI 1108Affinity Purified
SizeStorageShippingSourceHost
50ug4C/-20CBlue IceHumanMouse
Concentration:
1mg/ml
Immunogen:
Recombinant human IL-23p40.
Purity:
Purified by Protein A affinity chromatography.
Form
Supplied as a liquid in 0.2um-filtered PBS, pH 7.4. No preservative added.
Specificity:
Recognizes human IL-23p40. Does not cross-react with human IL-23p19.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.