Technical Data
IL-23p40 (Interleukin-23 Subunit p40, IL-23 Subunit p40, Interleukin-12 Subunit beta, IL-12B, Cytotoxic Lymphocyte Maturation Factor 40kD Subunit, CLMF p40, IL-12 Subunit p40, NK Cell Stimulatory Factor Chain 2, NKSF2)
IL-23p40 associates with IL-23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 binds to an heterodimeric receptor complex composed of IL-12RB1 and IL-23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. Defects in IL-23p40 are a cause of mendelian susceptibility to mycobacterial disease (MSMD). Genetic variations in IL-23p40 are a cause of susceptibility to psoriasis type 11 (PSORS11).

Suitable for use in ELISA, Western Blot

Recommended Dilution:
Optimal dilutions to be determined by researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
MabIgG1,kI 1108Affinity Purified
50ug4C/-20CBlue IceHumanMouse
Recombinant human IL-23p40.
Purified by Protein A affinity chromatography.
Supplied as a liquid in 0.2um-filtered PBS, pH 7.4. No preservative added.
Recognizes human IL-23p40. Does not cross-react with human IL-23p19.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.