Technical Data
045036
MnTBAP chloride (Manganese (III) tetrakis (4-benzoic acid)porphyrin chloride)
10mg
Biochemicals Storage: 4C/-20CShipping: Blue Ice
Cell permeable superoxide dismutase (SOD) mimetic. Potent inhibitor of peroxynitrite-induced oxidative reactions (peroxynitrite scavenger), but not a scavenger of nitric oxide (NO). Neuronal apoptosis inhibitor. Protects T cells from superoxide generation, caspase-dependent DNA loss and cell death. Lipopolysaccharide-induced TNF-alpha production inhibitor, by prevention of intracellular ROS generation and subsequent inactivation of p38 MAPK and SAPK/JNK.

Storage and Stability:
Short-term Storage: +4C
Long-term Storage: -20C
Stable for at least 2 years after receipt when stored at -20C.

Molecular Formula:
C48H28MnN4O8Cl

Molecular Weight:
879.2
Purity: >97% (MS)

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Product Reference:
Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo: K.M. Faulkner, et al.; J. Biol. Chem. 269, 23471 (1994)
A metalloporphyrin superoxide dismutase mimetic protects against paraquat-induced endothelial cell injury, in vitro: B.J. Day, et al.; J. Pharm. Exp. Ther. 275,1227 (1995)
Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger: C. Szabó, et al.; FEBS Lett. 381, 82 (1996)
Inhibition of neuronal apoptosis by a metalloporphyrin superoxide dismutase mimic: M. Patel; J. Neurochem. 71, 1068 (1998)
Reactive oxygen species regulate activation-induced T cell apoptosis: D.A. Hildeman, et al.; Immunity 10, 735 (1999)
MnTBAP, a synthetic metalloporphyrin, inhibits production of tumor necrosis factor-alpha in lipopolysaccharide-stimulated RAW 264.7 macrophages cells via inhibiting oxidative stress-mediating p38 and SAPK/JNK signaling: G. Tumurkhuu, et al.; FEMS Immunol. Med. Microbiol. 49, 304 (2007)


Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.