Technical Data
A0004-75A
ABIN-1 (A-20 binding Inhibitor of Nuclear Factor-kappaB (NF-kB) Activation)
|
Technical Data |
|
A0004-75A |
ABIN-1 (A-20 binding Inhibitor of Nuclear Factor-kappaB (NF-kB) Activation) |
|
|
Description: A20-binding inhibitor of NFkB activation (ABIN-1) is involved in NFkB-dependent gene expression and plays an important role in numerous cellular processes including stress responses, inflammation and cell proliferation. ABIN-1 increases cell surface CD4 (T4) antigen expression, and it interacts with HIV-1 matrix protein and is packaged into virions. Overexpression of ABIN-1can .inhibit viral replication. ABIN-1 may also regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. ABIN-1 is strongly expressed in peripheral blood lymphocytes, spleen and skeletal muscle, and is weakly expressed in the brain. Applications: Suitable for use in ELISA, Immunoprecipitation and Western Blot. Other applications have not been tested. Recommended Dilutions: ELISA (Immunogen): 0.1-1ug/ml Immunoprecipitatio (Human): 7-10ug/test Western Blot (Human): 1-3ug/ml Optimal dilutions to be determined by the researcher. Positive Control: HEK-293 cell lysate. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
|
|||||||||||
|
||||||||||||
|
||||||||||||
|
||||||||||||