Technical Data
A1362-86
Amyotrophic lateral sclerosis protein 2 (ALS2)
Description:
Amyotrophic lateral sclerosis protein 2 (ALS2) or Alsin is a 184kD protein that contains three guanine-nucleotide exchange factor domains and may act as a GTPase regulator. ALS2 dysfunction affects endosome trafficking through a Rab5 small GTPases family-mediated mechanism. It is a causative gene for a juvenile autosomal recessive form of motor neuron diseases, including amyotrophic lateral sclerosis 2. This disorder is characterized by a progressive degeneration of the upper motor neurons of the motor cortex and the lower motor neurons of the brain stem and spinal cord.

Applications:
Suitable for use in ELISA. Other applications not tested.

Recommended Dilution:
ELISA: 1:50
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
TypeIsotypeCloneGrade
PabAffinity Purified
SizeStorageShippingSourceHost
1mg-20CBlue IceHumanRabbit
Concentration:
As reported
Immunogen:
Synthetic peptide (LKACYYQIQREKLN) corresponding to aa1644-1657 of human ALS2
Purity:
Purified by Protein G affinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.2.
Specificity:
Recognizes human ALS2
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Yang, Y. et al. (2001) Nat. Genet. 29,160-165. Hadano, S. et al. (20001) Nat. Genet. 166-173. Chandran, J. et al. (2007) Mol. Neurobiol. 224-231. Hadano, S. et al. (2007) Neurochem. Int. 51,74-84.