Technical Data
Antibiotic LL Z1640-2 (Antibiotic C292, Antibiotic L 783278)
Biochemicals Storage: -20CShipping: Blue Ice
Antibiotic LL Z1640-2 a cis-enone resorcylic acid lactone first reported in 1978 and later rediscovered as an irreversible and highly selective TAK 1 inhibitor. TAK1 is a MAPKKK involved in the p38 signalling cascade for pro-inflammation signals such as cytokines. LL Z1640-2 effectively prevents inflammation in an animal models.

Antibiotic LL Z1640-2

Molecular Weight:

Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

Storage and Stability:
Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with ethanol, methanol, DMF or DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

CAS Number:

Molecular Formula:

Molecular Weight:
Source: Curvularia sp. MST-FP2097
Purity: 95% by HPLC
Form: Supplied as a white solid.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards:All products should be handled by qualified personnel only, trained in laboratory procedures.
1. New zearalenone related macrolides and isocoumarins from an unidentified fungus. Ellestad, G.A., et al., J. Org. Chem. 43: 2339 (1978). 2. A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase. Ninomiya-Tsuji, J., et al., J. Biol. Chem. 278: 18,485 (2003).

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.