Technical Data
A2298-75
Aphidicolin
5mg
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Technical Data |
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A2298-75 |
Aphidicolin |
5mg |
| Biochemicals | Storage: -20°CShipping: RT |
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Aphidicolin is a tetracyclic diterpene antibiotic isolated from species in several genera of fungi, notably Cephalosporium, Nigrospora, Harziella and Phoma. Aphidicolin has antibiotic, antiviral and antimitotic properties blocking the cell cycle at early S-phase. This property has been used to synchronize cell division and has found use as a tool in cell differentiation research. Aphidicolin is a reversible inhibitor of DNA replication by inhibition of selected DNA polymerases. Aphidicolin induces apoptosis, prolongs the half-life of DNA methyltransferase, is active against Leishmania parasites and acts synergistically with the antitumor agents, vincristine and doxorubicin. Nomenclature: 3-a,4-a,5-a,17-a-3,17-Dihydroxy-4-methyl-9,15-cyclo-C,18-dinor-14,15-secoandrostane-4,17-dimethanol Melting Point: 225-233°C Appearance: Supplied as a white to off-white crystalline powder. Solubility: Soluble in DMSO (50mg/ml). Also soluble in Ethanol and Methanol. Handling: Warning! Toxic. Aphidicolin may be Carcinogenic. Wear gloves/mask when handling product. Avoid contact by all modes of exposure. Storage and Stability: Lyophilized powder may be stored at 4°C. Lyophilized powder is stable for 12 months as supplied. Reconstitute to nominal volume by adding DMSO, ethanol or methanol. Aliquot and store at -20°C. Reconstituted product is stable for 1-2 months at -20°C. Further dilutions can be made in assay buffer. Note: Aphidicolin extremely hygroscopic. Protect from moisture. Store in tightly sealed vial under inert gas. Warm to RT before opening container. CAS Number: 38966-21-1 Molecular Formula: C20H34O4 Molecular Weight: 338.5 |
Source: Nigrospora oryzae Purity: 98% Form: Supplied as a white crystalline powder Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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1. Merck Index 12: 769.
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