Technical Data
A2299-85
Apoptolidin
100ug
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Technical Data |
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A2299-85 |
Apoptolidin |
100ug |
| Biochemicals | Storage: -20°CShipping: Blue Ice |
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Apoptolidin, originally isolated from a Nocardiopsis sp., induces apoptotic cell death in rat glial cells transformed with the adenovirus E1A oncogene at an IC50 = 11 ng/ml. It is among the most selective cytotoxic agents tested by the NCI in human cancer cell lines. Although the apoptotic activity of apoptolidin correlates with F0F1-ATPase inhibition, recent evidence suggests the existence of a secondary biological target or more complex mode of action. Purity: >95% by HPLC Solubility: Soluble in ethanol, methanol, DMF or DMSO Related to: Isoapoptolidin CAS Number: 194874-06-1 Molecular Formula: C58H96O21 Molecular Weight: 1129.37 |
Source: Amycolatopsis sp Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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1. Correlation of F0F1-ATPase inhibition and antiproliferative activity of apoptolidin analogues. Wender P.A. et al. Org. Lett. 2006, 8, 589. 2. Apoptolidin: induction of apoptosis by a natural product. Daniel P.T. et al. Angew. Chem. Int. Ed. Engl. 2006, 45, 872. 3. Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F(0)F(1)-ATPase. Salomon A.R. et al. Proc. Natl Acad. Sci. USA. 2000, 97, 14766. 4. Apoptolidin, a new apoptosis inducer in transformed cells from Nocardiopsis sp. Kim J.W. et al. J. Antibiot. 1997, 50, 628.
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