Technical Data
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Apoptolidin, originally isolated from a Nocardiopsis sp., induces apoptotic cell death in rat glial cells transformed with the adenovirus E1A oncogene at an IC50 = 11 ng/ml. It is among the most selective cytotoxic agents tested by the NCI in human cancer cell lines. Although the apoptotic activity of apoptolidin correlates with F0F1-ATPase inhibition, recent evidence suggests the existence of a secondary biological target or more complex mode of action.

Purity: >95% by HPLC

Solubility: Soluble in ethanol, methanol, DMF or DMSO

Related to: Isoapoptolidin

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Source: Amycolatopsis sp

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Correlation of F0F1-ATPase inhibition and antiproliferative activity of apoptolidin analogues. Wender P.A.
et al. Org. Lett. 2006, 8, 589.
2. Apoptolidin: induction of apoptosis by a natural product. Daniel P.T. et al. Angew. Chem. Int. Ed. Engl.
2006, 45, 872.
3. Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of
F(0)F(1)-ATPase. Salomon A.R. et al. Proc. Natl Acad. Sci. USA. 2000, 97, 14766.
4. Apoptolidin, a new apoptosis inducer in transformed cells from Nocardiopsis sp. Kim J.W. et al. J.
Antibiot. 1997, 50, 628.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.