Technical Data
A3570-66L3
ARHGAP20 (Rho GTPase-activating Protein 20, Rho-type GTPase-activating Protein 20, KIAA1391)
Description:
RhoGap20 encodes a potent Rho GTPase-activating protein, which is a direct downstream target of Rap1 in the neurite outgrowth. Overexpression of the protein induced inactivation of Rho for promoting the neurite outgrowth in a Rap1-dependent manner. It is also involved in rearrangements of the cytoskeleton and cell signaling events that occur during spermatogenesis. RhoGap20 gene is predicted to be a tumor suppressor, inactivated by deletion in breast cancer and also by chromosomal translocation in B-cell chronic lymphocytic leukemia. The protein is expressed in human brain, liver, ovary and spinal cord. The gene encoding for rat RhoGap20 is localized on chromosome 8q24.

Applications:
Suitable for use in ELISA. Other applications not tested.

Recommended Dilution:
ELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGSerum
SizeStorageShippingSourceHost
100ul-20CBlue IceRatRabbit
Concentration:
Not determined.
Immunogen:
Synthetic peptide corresponding to aa749-762 ([BLAST]HEGNQETPFTKSKP[BLAST]) of rat RhoGap20.
Purity:
Serum
Form
Supplied as a liquid, 0.025% sodium azide, 50% glycerol.
Specificity:
Recognizes rat RhoGap20. Species sequence homology: mouse.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Yamada, T. et al. J. Biol. Chem. 280:33026-33034 (2005).