Technical Data
A3698-75
Ascomycin (Immunomycin, FK-520, FR-520, NSC-106410, FR 900520, L 683590)
5mg
Biochemicals Storage: -20CShipping: Blue Ice
Ascomycin inhibits the production of T helper type 1 (Th1) (interferon and IL-2) and Th2 (IL-4 and IL-10) cytokines in target cells.

Solubility:
Soluble in DMSO at 65mg/mL; soluble in ethanol at 50mg/mL with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-50uM; buffers, serum, or other additives may increase or decrease the aqueous solubility.

Melting Point:
154.5-160C

Storage and Stability:
May be stored at RT for short-term only. Long-term storage is recommended at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

CAS Number:
104987-12-4

Molecular Formula:
C43H69NO12

Molecular Weight:
792.01
Purity: ~99%
Form: Supplied as a white to off-white powder.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Paul, C., et al. "Ascomycins: promising agents for the treatment of inflammatory skin diseases." Expert Opin. Investig. Drugs. 9:69-77 (2000). 2. Mollison, K.W., et al. "A macrolactam inhibitor of T helper type 1 and T helper type 2 cytokine biosynthesis for topical treatment of inflammatory skin diseases." J. Invest. Dermatol. 112:729-738 (1999). 3. Monaghan, P., et al. "Antimalarial effects of macrolactones related to FK520 (ascomycin) are independent of the immunosuppressive properties of the compounds." J. Infect. Dis. 191:1342-1349 (2005). 4. Raymond, M., et al. "Functional expression of P-glycoprotein in Saccharomyces cerevisiae confers cellular resistance to the immunosuppressive and antifungal agent FK520." Mol. Cell Biol. 14:277-286 (1994).

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.