Technical Data
A3698-75
Ascomycin (Immunomycin, FK-520, FR-520, NSC-106410, FR 900520, L 683590)
5mg
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Technical Data |
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A3698-75 |
Ascomycin (Immunomycin, FK-520, FR-520, NSC-106410, FR 900520, L 683590) |
5mg |
| Biochemicals | Storage: -20°CShipping: Blue Ice |
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Ascomycin inhibits the production of T helper type 1 (Th1) (interferon and IL-2) and Th2 (IL-4 and IL-10) cytokines in target cells. Solubility: Soluble in DMSO at 65mg/mL; soluble in ethanol at 50mg/mL with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-50uM; buffers, serum, or other additives may increase or decrease the aqueous solubility. Melting Point: 154.5-160ºC Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. CAS Number: 104987-12-4 Molecular Formula: C43H69NO12 Molecular Weight: 792.01 |
Purity: ~99% Form: Supplied as a white to off-white powder. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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1. Paul, C., et al. "Ascomycins: promising agents for the treatment of inflammatory skin diseases." Expert Opin. Investig. Drugs. 9:69-77 (2000). 2. Mollison, K.W., et al. "A macrolactam inhibitor of T helper type 1 and T helper type 2 cytokine biosynthesis for topical treatment of inflammatory skin diseases." J. Invest. Dermatol. 112:729-738 (1999). 3. Monaghan, P., et al. "Antimalarial effects of macrolactones related to FK520 (ascomycin) are independent of the immunosuppressive properties of the compounds." J. Infect. Dis. 191:1342-1349 (2005). 4. Raymond, M., et al. "Functional expression of P-glycoprotein in Saccharomyces cerevisiae confers cellular resistance to the immunosuppressive and antifungal agent FK520." Mol. Cell Biol. 14:277-286 (1994).
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