Technical Data
B2105-59
Bleomycin complex (as sulfate salts) (Blenoxane, Bleo, Blexane)
10mg
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Technical Data |
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B2105-59 |
Bleomycin complex (as sulfate salts) (Blenoxane, Bleo, Blexane) |
10mg |
| Biochemicals | Storage: -20°CShipping: Blue Ice |
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Bleomycin is a complex of 11 glycopeptide antitumor antibiotics originally isolated from Streptomyces verticillus in 1972. The dominant components of the complex are bleomycin A2 and B2 and typically represent >90% of the total weight with the remainder comprising the minor analogues. Bleomycins have found clinical application in the treatment of a range of tumors. Bleomycins act by intercalation of DNA and RNA. In the presence of oxygen and metal ions, notably copper and iron, bleomycins form a pseudo- enzyme that induces DNA cleavage. Solubility: Soluble in water, methanol with moderate ethanol solubility Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. CAS Number: 9041-93-4 Molecular Formula: C55H84N17O21S+. H2SO4 Molecular Weight: 1513.6 |
Source: Streptomyces sp. MST-AS4458 Purity: ~99% Form: Supplied as an off-white solid. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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1. Takita T. et al., J. Antibiot. 1972, 25, 755. 2. Kross J. et al., Biochemistry 1982, 21, 3711. 3. Kross et al., Biochemistry 1982, 21, 4310.
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