Technical Data
Bleomycin complex (as sulfate salts) (Blenoxane, Bleo, Blexane)
Biochemicals Storage: -20CShipping: Blue Ice
Bleomycin is a complex of 11 glycopeptide antitumor antibiotics originally isolated from Streptomyces verticillus in 1972. The dominant components of the complex are bleomycin A2 and B2 and typically represent >90% of the total weight with the remainder comprising the minor analogues. Bleomycins have found clinical application in the treatment of a range of tumors. Bleomycins act by intercalation of DNA and RNA. In the presence of oxygen and metal ions, notably copper and iron, bleomycins form a pseudo- enzyme that induces DNA cleavage.

Solubility: Soluble in water, methanol with moderate ethanol solubility

Storage and Stability:
Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. Reconstituted product is stable for 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

CAS Number:

Molecular Formula:
C55H84N17O21S+. H2SO4

Molecular Weight:
Source: Streptomyces sp. MST-AS4458
Purity: ~99%
Form: Supplied as an off-white solid.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Takita T. et al., J. Antibiot. 1972, 25, 755. 2. Kross J. et al., Biochemistry 1982, 21, 3711. 3. Kross et al., Biochemistry 1982, 21, 4310.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.