Technical Data
Bone Morphogenetic Protein 2, Recombinant, Human (BMP-2) (Human Cells)
Molecular Biology Storage: -20CShipping: Blue Ice
BMP-2 belongs to the bone morphogenetic protein family, a subgroup of the TGF-beta superfamily. BMP-2 is important during embryogenesis especially for skeletal developement and induces chondrocytes formation and osteoblast differentation. BMPs are involved in dorsal-ventral patterning of the embryo and organogenesis.

Recombinant protein corresponding to Human BMP-2 expressed in engineered human cells as a glycosylated dimer with an apparent molecular mass of 30-38kD.

The specific activity was determined by its ability to induce alkaline phosphatase production in a dose response to BMP-2 in the ATDC-5 cell line (Mouse chondrogenic cell line).

Specific Activity:
~10-100ng/ml ED50

Storage and Stability:
Lyophilized powder may be stored at -20C. Stable for 6 months after receipt at -20C. Reconstitute with sterile 4mM HCl, 0.1% endotoxin-free recombinant HSA. Aliquot and store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight:
Purity: 90% as determined by SDS-PAGE and stained with Coomassie blue. Endotoxin: 1EU/ug (LAL).
Form: Supplied as a lyophilized powder from PBS. Reconstitute with sterile 4mM HCl, 0.1% endotoxin-free recombinant HSA.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Chen, D. et al. Growth Factors 22; 233-241 (2004) 2. Nakamura k etal. Exp cell Research 250; 351-363 (1999).

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.